The Bioinformatics Laboratory pursues two lines of research in areas important for the AMC. This research is generally implemented with groups within and outside the AMC. Systems Genomics aims at the analysis and interpretation of genome-wide omics data in the context of biological networks. Information Management focusses on the use of semantic web technologies for the organisation and integration of biomedical data, information and knowledge.
Results from this research will largely facilitate systems biology research (which is a AMC and UvA spearhead). For example, Systems Genomics contributes to the reconstruction, analysis and interpretation of biological networks. The biomedical knowledge bases developed within Semantic Biosystems organize biological and clinical information, including high-quality definition of pathways and their relation to specific disorders, which will serve as input of mathematical modeling and simulation. e-Bioscience will provide the data- and computational (Grid) infrastructure that is necessary for systems biology.
We also aim to maximize synergy between these research lines and other activities of the lab. For example, the analysis and comparison of biological pathway databases with Systems Genomics provides important information for the development of biomedical knowledgebases with Information Management. Similarly, the infrastructure developed in e-Bioscience is currently used for the analysis of next-generation sequence data.